胸腔内压力对人体肺压力-容积特性的影响。

Effect of intrathoracic pressure on pressure-volume characteristics of the lung in man.

作者信息

Goldberg H S, Mitzner W, Adams K, Menkes H, Lichtenstein S, Permutt S

出版信息

J Appl Physiol. 1975 Mar;38(3):411-7. doi: 10.1152/jappl.1975.38.3.411.

DOI:10.1152/jappl.1975.38.3.411

Abstract

Quasi-static pressure-volume (P-V) curves in normal seated human subjects were determined with pressure at the airway opening (Pa0) set below (negative pressure), above (positive pressure), or equal to ambient pressure. Dynamic compliance (Cdyn) during controlled continuous negative pressure breathing (CNPB) was also studied. Quasi-static P-V curves at negative pressure were decreased in slope, reflected a decrease in total lung capacity, and intersected the P-V curve obtained at ambient Pa0. At positive pressure the P-V curves showed an increase in slope and an increase in total lung capacity. During CNPB a fall in Cdyn was found. The fall in Cdyn was rapid and persisted for the duration of CNPB. Cdyn promptly returned to control levels when Pa0 was adjusted to ambient pressure.

摘要

在正常坐姿人体受试者中，通过将气道开口处压力（Pa0）设置为低于（负压）、高于（正压）或等于环境压力来测定准静态压力-容积（P-V）曲线。还研究了控制性持续负压呼吸（CNPB）期间的动态顺应性（Cdyn）。负压下的准静态P-V曲线斜率降低，反映肺总量减少，并与在环境Pa0下获得的P-V曲线相交。正压下P-V曲线斜率增加且肺总量增加。在CNPB期间发现Cdyn下降。Cdyn下降迅速并在CNPB持续期间持续存在。当Pa0调整到环境压力时，Cdyn迅速恢复到对照水平。