Kaspar R L, Barnes G E, Peterson D F, Bishop V S
J Appl Physiol. 1975 Mar;38(3):485-90. doi: 10.1152/jappl.1975.38.3.485.
A possible role of the autonomic nervous system in the left ventricular response to acute regional myocardial ischemia was sought in conscious dogs instrumented for measurement of left ventricular pressure, internal diameter, and aortic flow. Ischemia produced by occluding the left circumflex coronary artery caused tachycardia and reduced contractility. Changes during control occlusions were compared with those during occlusion.s after beta-adrenergic blockade, parasympathetic blockade, and combined sympathetic and parasymphatetic blockade. Beta-blockade did reduce the tachycardia and slightly reduced left ventricular diameter changes in response to coronary occlusion. Results obtained in animals following surgical cardiac sympathectomy indicated reduced tachycardia and no effects on other parameters. The principal effect of parasympathetic blockade was to augment the increase in end diastolic diameter during occlusion Right atrial pacing indicated this change was due to higher initial heart rates. Combined parasympathetic and sympathetic blockade did not alter inotropic responses to coronary occlusion. Results indicated that inotropic support due to changes in activity in autonomic nerves is not increased during acute occlusion of the left circumflex coronary artery.
在植入了用于测量左心室压力、内径和主动脉血流量的仪器的清醒犬中，研究了自主神经系统在左心室对急性局部心肌缺血反应中的可能作用。通过阻塞左旋冠状动脉产生的缺血导致心动过速并降低收缩力。将对照阻塞期间的变化与β-肾上腺素能阻断、副交感神经阻断以及交感神经和副交感神经联合阻断后的阻塞期间的变化进行比较。β-阻断确实减少了心动过速，并略微减少了冠状动脉阻塞时左心室直径的变化。心脏交感神经切除术后动物的结果表明心动过速减少，对其他参数无影响。副交感神经阻断的主要作用是增加阻塞期间舒张末期直径的增加。右心房起搏表明这种变化是由于较高的初始心率。副交感神经和交感神经联合阻断并未改变对冠状动脉阻塞的变力反应。结果表明，在左旋冠状动脉急性阻塞期间，自主神经活动变化引起的变力支持并未增加。
