Fara J W, Barth K H, White R I, Bynum T E
Radiology. 1979 Nov;133(2):317-20. doi: 10.1148/133.2.317.
Mesenteric vascular effects of prostaglandins B2 and F2 alpha were studied and compared to those of vasopressin in the dog, cat and baboon. Vasopressin reduced superior mesenteric blood flow (SMBF) 80-100%, and significantly increased hepatic arterial blood flow and systemic arterial pressure. Prostaglandin B2 produced vasodilatation at low doses and biphasic vasodilatation/vasoconstriction at high doses. Prostaglandin F2 alpha elicited only vasoconstriction, reducing SMBF, left gastric, and inferior mesenteric blood flow 80-100%. Systemic arterial pressure was not significantly changed. Thus, vasopressin and prostaglandin F2 alpha are equally effective mesenteric vasoconstrictors. Because of reduced systemic effects, prostaglandin F2 alpha has excellent potential as a mesenteric vasoconstrictor to control gastrointestinal hemorrhage.
研究了前列腺素B2和F2α对犬、猫和狒狒肠系膜血管的作用，并与血管加压素的作用进行了比较。血管加压素使肠系膜上血流量（SMBF）减少80%-100%，并显著增加肝动脉血流量和体动脉压。前列腺素B2在低剂量时产生血管舒张，在高剂量时产生双相血管舒张/血管收缩。前列腺素F2α仅引起血管收缩，使SMBF、胃左动脉和肠系膜下动脉血流量减少80%-100%。体动脉压无显著变化。因此，血管加压素和前列腺素F2α是同样有效的肠系膜血管收缩剂。由于全身作用减弱，前列腺素F2α作为控制胃肠道出血的肠系膜血管收缩剂具有极好的潜力。
