Mikulová R, Hainer V
Centrum pro diagnostiku a lécbu obezity III. interní kliniky 1. LF UK a VFN, Praha.
Cas Lek Cesk. 2001 Jun 5;140(13):387-91.
Uncoupling proteins are located in the inner mitochondria membrane. Their name is derived from their function: they uncouple oxidative procesess of the respiratory chain from ATP synthesis. Hitherto several members of the family have been described, the best known being UCP1. UCP1 can be expressed exclusively in brown adipose tissue and it is responsible for the heat production. In humans the brown fat disappears during the early childhood. In adults another members of the UCP family can be found--UCP2 and UCP3. It is widely accepted that these proteins affect lipid metabolism and energy expenditure. They are intensively studied owing to their possible use in the therapy of obesity. However, their physiological function has not been yet fully established.
解偶联蛋白位于线粒体内膜。它们的名字源于其功能：使呼吸链的氧化过程与ATP合成解偶联。迄今为止，该家族已被描述的有几个成员，最著名的是UCP1。UCP1仅在棕色脂肪组织中表达，负责产热。在人类中，棕色脂肪在幼儿期消失。在成年人中可以发现UCP家族的其他成员——UCP2和UCP3。人们普遍认为这些蛋白质会影响脂质代谢和能量消耗。由于它们可能用于肥胖症治疗，因此受到深入研究。然而，它们的生理功能尚未完全明确。
