Razagui I B, Haswell S J
University of Hull Postgraduate Medical School, Academic Department of Obstetrics and Gynaecology, Hull Maternity Hospital, United Kingdom.
Biol Trace Elem Res. 2001 Jul;81(1):1-19. doi: 10.1385/BTER:81:1:01.
Mercury and selenium concentrations were determined in scalp hair samples collected postpartum from 82 term pregnancy mothers and their neonates. Maternal mercury and selenium had median concentrations of 0.39 microg/g (range 0.1-2.13 microg/g) and 0.75 microg/g (range 0.1-3.95 microg/g), respectively, and corresponding median neonatal values were 0.24 microg/g (range 0.1-1.93 microg) and 0.52 microg/g (range (0.1-3.0 microg/g). Amalgam-based restorative dental treatment received during pregnancy by 27 mothers (Group I) was associated with significantly higher mercury concentrations in their neonates (p < 0.0001) compared to those born to 55 mothers (Group II) whose most recent history of such dental treatment was dated to periods ranging between 1 and 12 yr prior to pregnancy. In the Group I mother/neonate pairs, amalgam removal and replacement in 10 cases was associated with significantly higher mercury concentrations compared to 17 cases of new amalgam emplacement. Selenium concentrations showed no significant intergroup differences. However, the selenium/mercury molar ratio values were lowest in the Group I neonates, compared to their mothers and to the Group II mother/neonate pairs. This ratio decreased as mercury concentration increased, and this interrelation was statistically significant in both groups of mother/neonate pairs. The data from this preliminary study suggest that amalgam-based dental treatment during pregnancy is associated with higher prenatal exposure to mercury, particularly in cases of amalgam removal and replacement. The ability of a peripheral biological tissue, such as hair, to elicit such marked differences in neonatal mercury concentrations provides supporting evidence of high fetal susceptibility to this form of mercury exposure. The data are discussed in relation to the differences between maternal and fetal mercury metabolisms and to mercury-selenium metabolic intereactions in response to mercury exposure.
对82名足月妊娠母亲及其新生儿产后采集的头皮毛发样本中的汞和硒浓度进行了测定。母亲的汞和硒中位浓度分别为0.39微克/克（范围0.1 - 2.13微克/克）和0.75微克/克（范围0.1 - 3.95微克/克），相应的新生儿中位值分别为0.24微克/克（范围0.1 - 1.93微克）和0.52微克/克（范围0.1 - 3.0微克/克）。27名母亲（第一组）在孕期接受了基于汞合金的修复性牙科治疗，与55名母亲（第二组）所生新生儿相比，她们的新生儿汞浓度显著更高（p < 0.0001），第二组母亲最近一次此类牙科治疗的时间可追溯到怀孕前1至12年。在第一组母亲/新生儿对中，10例汞合金去除和替换病例的汞浓度显著高于17例新放置汞合金的病例。硒浓度在组间无显著差异。然而，与母亲以及第二组母亲/新生儿对相比，第一组新生儿的硒/汞摩尔比值最低。该比值随着汞浓度的增加而降低，并且这种相互关系在两组母亲/新生儿对中均具有统计学意义。这项初步研究的数据表明，孕期基于汞合金的牙科治疗与更高的产前汞暴露有关，尤其是在汞合金去除和替换的情况下。像毛发这样的外周生物组织能够在新生儿汞浓度上引发如此显著差异，这为胎儿对这种汞暴露形式的高易感性提供了支持证据。讨论了这些数据与母体和胎儿汞代谢差异以及汞暴露时汞 - 硒代谢相互作用之间的关系。
