核质运输：扩散通道还是相变？

Nucleocytoplasmic transport: diffusion channel or phase transition?

作者信息

Rabut G, Ellenberg J

机构信息

Gene Expression and Cell Biology/Biophysics Programmes, European Molecular Biology Laboratory (EMBL), Meyerhofstrasse 1, D-69117, Heidelberg, Germany.

出版信息

Curr Biol. 2001 Jul 24;11(14):R551-4. doi: 10.1016/s0960-9822(01)00340-2.

DOI:10.1016/s0960-9822(01)00340-2

PMID:11509251

Abstract

How exactly large molecules translocate through nuclear pores has been mysterious for a long time. Recent kinetic measurements of transport rates through the pore have led to a novel translocation model that elegantly combines selectivity with very high transport rates.

摘要

很长一段时间以来，大分子究竟是如何穿过核孔的一直是个谜。最近对通过核孔的运输速率进行的动力学测量得出了一个新颖的转运模型，该模型巧妙地将选择性与非常高的运输速率结合在一起。