Yoshida S, Ektessabi A, Fujisawa S
Department of Neurology, Wakayama Medical College, Japan.
J Synchrotron Radiat. 2001 Mar 1;8(Pt 2):998-1000. doi: 10.1107/s0909049500017726.
Chemical state of transition metals such as iron in a single neuron of the substantia nigra (SN) from a patient with Parkinson's disease (PD) was studied in this paper, using autopsy midbrain specimens including SN. Parkinson's disease is one of the major neurodegenerative diseases. The excessive accumulation of iron and its chemical states in SN neurons are related to the oxidative damage leading to neuronal cell death. X-ray absorption fine structure spectroscopy (XAFS) with SR micro beam (10 microm) was used to investigate the chemical state of iron in the SN neurons. X-ray absorption near-edge structure (XANES) spectroscopy results showed that the chemical state of iron in the neuromelanin granules within SN neurons changed from ferrous (Fe2+) to ferric (Fe3+) ion in the process of neuronal degeneration.
本文利用包括黑质（SN）在内的尸检中脑标本，研究了帕金森病（PD）患者黑质单个神经元中铁等过渡金属的化学状态。帕金森病是主要的神经退行性疾病之一。黑质神经元中铁的过度积累及其化学状态与导致神经元细胞死亡的氧化损伤有关。使用具有同步辐射微束（10微米）的X射线吸收精细结构光谱（XAFS）来研究黑质神经元中铁的化学状态。X射线吸收近边结构（XANES）光谱结果表明，在神经元变性过程中，黑质神经元内神经黑色素颗粒中铁的化学状态从亚铁（Fe2+）离子转变为铁（Fe3+）离子。
