Kisselev A F, Goldberg A L
Department of Cell Biology, Harvard Medical School, 240 Longwood Ave., Boston, MA 02115, USA.
Chem Biol. 2001 Aug;8(8):739-58. doi: 10.1016/s1074-5521(01)00056-4.
The 26S proteasome is a 2.4 MDa multifunctional ATP-dependent proteolytic complex, which degrades the majority of cellular polypeptides by an unusual enzyme mechanism. Several groups of proteasome inhibitors have been developed and are now widely used as research tools to study the role of the ubiquitin-proteasome pathway in various cellular processes, and two inhibitors are now in clinical trials for treatment of multiple cancers and stroke.
26S蛋白酶体是一种分子量为2.4兆道尔顿的多功能ATP依赖性蛋白水解复合物，它通过一种独特的酶机制降解大多数细胞多肽。现已开发出几组蛋白酶体抑制剂，目前作为研究工具被广泛用于研究泛素-蛋白酶体途径在各种细胞过程中的作用，并且有两种抑制剂目前正处于治疗多种癌症和中风的临床试验阶段。
