Abdelmelek H, Fechtali T, Filali-Zegzouti Y, Rouanet J L, Cottet-Emard J M, Pequignot J M, Barré H
Laboratoire de Physiologie des Régulations Energétiques, Cellulaires et Moléculaires UMR 5578 CNRS, Villeurbanne, France.
J Neural Transm (Vienna). 2001;108(7):793-801. doi: 10.1007/s007020170029.
Recent investigations have demonstrated a modulatory action of glucagon on shivering via the central nervous system in ducklings. The aim of this study was to investigate the effects of intracerebroventricular injection (i.c.v.) of glucagon on metabolic rates (MR) and plasma catecholamines in control ducklings (TN) and in ducklings exhibiting nonshivering thermogenesis after chronic glucagon treatment: (GT). At thermoneutrality (25 degrees C, Ta), i.c.v. injection of glucagon had no thermogenic effects in TN and GT ducklings. At cold (+4 degrees C, Ta), i.c.v. glucagon injection elicited a concomitant decrease of plasma norepinephrine (NE) and MR in TN ducklings, whereas in GT ducklings, the plasma catecholamines and the MR remained unchanged. These results indicate that glucagon treatment rendered the catecholaminergic system of GT ducklings insensitive to cold or i.c.v. glucagon injection.
最近的研究表明，胰高血糖素可通过中枢神经系统对雏鸭的颤抖产生调节作用。本研究的目的是调查向对照雏鸭（TN）和经慢性胰高血糖素处理后表现出非颤抖性产热的雏鸭（GT）脑室内注射（i.c.v.）胰高血糖素对代谢率（MR）和血浆儿茶酚胺的影响。在热中性环境（25摄氏度，Ta）下，向TN和GT雏鸭脑室内注射胰高血糖素没有产热作用。在寒冷环境（4摄氏度，Ta）下，向TN雏鸭脑室内注射胰高血糖素会使血浆去甲肾上腺素（NE）和MR同时降低，而在GT雏鸭中，血浆儿茶酚胺和MR保持不变。这些结果表明，胰高血糖素处理使GT雏鸭的儿茶酚胺能系统对寒冷或脑室内注射胰高血糖素不敏感。
