Javidan S, Mrtek R G
J Pharm Sci. 1975 Mar;64(3):420-4. doi: 10.1002/jps.2600640314.
The protein binding characteristics of chloramphenicol, furazolium chloride, benzalkonium chloride, and phenylmercuric nitrate were described from their partitioning behavior in gelatin-acacia complex coacervate systems. Although the partitioning was determined by two different methods (microbiological and chemical), the microbiological method was more reliable for this type of investigation. Drug-protein parameters were calculated for the four antimicrobials. The advantages of the coacervate systems over other models for protein binding studies of drugs are discussed.
通过氯霉素、呋咱氯铵、苯扎氯铵和硝酸苯汞在明胶-阿拉伯胶复合凝聚系统中的分配行为，描述了它们的蛋白质结合特性。尽管分配是通过两种不同方法（微生物法和化学法）测定的，但微生物法对于此类研究更为可靠。计算了这四种抗菌剂的药物-蛋白质参数。讨论了凝聚系统相对于其他药物蛋白质结合研究模型的优势。
