York P
J Pharm Sci. 1975 Jul;64(7):1216-21. doi: 10.1002/jps.2600640721.
Powder failure testing equipment was used successfully to study the effect of glidants on the flowability of two cohesive pharmaceutical powders, lactose and calcium hydrogen phosphate, using the flow factor as the flowability parameter. Fine silica, magnesium stearate, and purified talc were investigated as glidants; for each host powder-glidant mixture, an optimum concentration of glidant was observed beyond which no further increase in flowability occurred. The order of efficiency of glidants for both host powders was fine silica greater than magnesium stearate greater than purified talc. The mode of action of the three glidants is discussed.
使用粉末流动性测试设备，以流动因子作为流动性参数，成功地研究了助流剂对两种具有粘性的药用粉末（乳糖和磷酸氢钙）流动性的影响。研究了微粉硅胶、硬脂酸镁和精制滑石粉作为助流剂的情况；对于每种主体粉末 - 助流剂混合物，观察到助流剂存在一个最佳浓度，超过该浓度流动性不会进一步增加。两种主体粉末的助流剂效率顺序为微粉硅胶大于硬脂酸镁大于精制滑石粉。讨论了三种助流剂的作用方式。
