Cagnacci A, Arangino S, Renzi A, Cagnacci P, Volpe A
Institute of Obstetrics and Gynecology, University of Modena, via del Pozzo 71, 41100 Modena, Italy.
Eur J Endocrinol. 2001 Sep;145(3):281-7. doi: 10.1530/eje.0.1450281.
To determine the correlation between insulin sensitivity (S(I)) obtained by the minimal model method applied to a frequently sampled (n=33) intravenous glucose tolerance test (FSIGT(33)), and values obtained by reduced FSIGTs, oral glucose tolerance test (OGTT), or fasting.
Retrospective analysis on tests performed in prospective studies.
A total of 78 FSIGT(33), and 59 OGTT were performed in non-diabetic women of which 10 were young cyclic females in the early follicular menstrual phase, 10 were young non-obese subjects with polycystic ovary syndrome (PCOS) and 30 were in post-menopause. Some of these individuals were investigated both prior to and during specified treatments. FSIGT(33) was transformed into FSIGT(22) and FSIGT(12) by removing samples from the analysis. Values of SI derived from reduced FSIGTs or calculations performed on glucose and insulin values observed in fasting conditions and/or during OGTT were related to those of FSIGT(33).
S(I) values derived from FSIGT(33) were highly correlated with those derived from FSIGT(22) (r=0.965) or FSIGT(12) (r=0.955), but were only weakly correlated with those derived from fasting or OGTT calculations (r below 0.5). Between-group (PCOS vs normal) or within-group (prior to and during treatment) comparisons showed that reduced FSIGTs were only slightly less powerful than FSIGT(33) in detecting differences in S(I).
In non-diabetic women, reduced FSIGTs but not calculations based on fasting or OGTT values may be used in place of FSIGT(33) to document S(I) and its variation.
确定应用于频繁采样（n = 33）静脉葡萄糖耐量试验（FSIGT(33)）的最小模型法所获得的胰岛素敏感性（S(I)），与简化FSIGT、口服葡萄糖耐量试验（OGTT）或空腹所获得的值之间的相关性。
对前瞻性研究中进行的试验进行回顾性分析。
对非糖尿病女性进行了总共78次FSIGT(33)和59次OGTT，其中10名是处于卵泡期早期的年轻周期性女性，10名是患有多囊卵巢综合征（PCOS）的年轻非肥胖受试者，30名是绝经后女性。这些个体中的一些在特定治疗之前和期间都进行了调查。通过从分析中去除样本，将FSIGT(33)转换为FSIGT(22)和FSIGT(12)。来自简化FSIGT或根据空腹条件下和/或OGTT期间观察到的葡萄糖和胰岛素值进行计算得出的S(I)值，与FSIGT(33)的S(I)值相关。
来自FSIGT(33)的S(I)值与来自FSIGT(22)的S(I)值高度相关（r = 0.965）或与来自FSIGT(12)的S(I)值高度相关（r = 0.955），但与来自空腹或OGTT计算得出的S(I)值仅呈弱相关（r低于0.5）。组间（PCOS与正常组）或组内（治疗前和治疗期间）比较表明，简化FSIGT在检测S(I)差异方面仅比FSIGT(33)稍弱。
在非糖尿病女性中，简化FSIGT而非基于空腹或OGTT值的计算可用于替代FSIGT(33)来记录S(I)及其变化。
