肥胖青少年口服与静脉葡萄糖耐量试验衍生的敏感性和分泌指数比较
Comparison of oral and intravenous glucose tolerance test derived sensitivity and secretory indices in obese adolescents.
作者信息
Brar Preneet C, Koren Dorit, Gallagher Paul R, Pendurthi Bhavana, Katz Lorraine E Levitt
机构信息
Department of Pediatrics, New York University School of Medicine, New York, NY 10016, USA.
出版信息
Clin Pediatr (Phila). 2013 Mar;52(3):247-53. doi: 10.1177/0009922812472251.
BACKGROUND
Insulin resistance increases type 2 diabetes risk in obese adolescents. Thus, quantitative tools measuring insulin sensitivity and secretion are important for risk assessment.
METHODS
Forty-four obese pubertal adolescents underwent oral glucose tolerance test (OGTT) and frequently sampled intravenous glucose tolerance test (FSIGT). We correlated OGTT-derived whole body sensitivity index (WBISI) with FSIGT-derived insulin sensitivity index (Si). Insulinogenic index (IGI) from OGTT was compared with acute insulin response to glucose (AIRg) from FSIGT.
RESULTS
Fasting insulin (r = -.64, P < .0005) and glucose (r = -.39 P ≤ .0005) predicted Si. The OGTT-derived index WBISI correlated with the FSIGT-derived Si (r = .608, P < .0005). IGI correlated with AIRg from FSIGT (r = .704, P < .0005).
CONCLUSIONS
OGTT-based measures correlated with FSIGT-derived measures of insulin sensitivity and secretion. In particular, we demonstrated that WBISI can be a reliable alternative to FSIGT-derived Si in clinical settings where OGTT is a more feasible option.
背景
胰岛素抵抗会增加肥胖青少年患2型糖尿病的风险。因此，测量胰岛素敏感性和分泌的定量工具对于风险评估很重要。
方法
44名肥胖青春期青少年接受了口服葡萄糖耐量试验（OGTT）和频繁采样静脉葡萄糖耐量试验（FSIGT）。我们将OGTT得出的全身敏感性指数（WBISI）与FSIGT得出的胰岛素敏感性指数（Si）进行了关联。将OGTT的胰岛素生成指数（IGI）与FSIGT的葡萄糖急性胰岛素反应（AIRg）进行了比较。
结果
空腹胰岛素（r = -0.64，P < 0.0005）和葡萄糖（r = -0.39，P ≤ 0.0005）可预测Si。OGTT得出的指数WBISI与FSIGT得出的Si相关（r = 0.608，P < 0.0005）。IGI与FSIGT的AIRg相关（r = 0.704，P < 0.0005）。
结论
基于OGTT的测量结果与FSIGT得出的胰岛素敏感性和分泌测量结果相关。特别是，我们证明在OGTT是更可行选择的临床环境中，WBISI可以成为FSIGT得出的Si的可靠替代指标。
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