Aoki Y J, Kameko M, Fujita K
Clinical Laboratory, Nagano Municipal Hospital, Nagano 381-8551.
Rinsho Byori. 2001 Jul;49(7):686-9.
We report a human IgG4-lambda type M-protein that reacts with reagents of albumin, direct bilirubin and iron. Blood chemistry findings by an automated analyzer were: total protein 8.8 g/dl; albumin(ALB) 9.2 g/dl; direct bilirubin(D-Bil) -6.2 mg/dl; and iron(Fe) 25 micrograms/dl. The white precipitates were formed by the interaction of the patient's serum with reagents of ALB, D-Bil, and Fe. Immunofixation electrophoresis revealed that these precipitates were the IgG4-lambda type M-protein. Western blotting analysis showed that the IgG4 molecules were composed of two 55 kDa gamma 4 chains and two 24 kDa lambda chains.
我们报告了一种与白蛋白、直接胆红素和铁的试剂发生反应的人IgG4-λ型M蛋白。自动分析仪检测的血液化学结果为：总蛋白8.8g/dl；白蛋白（ALB）9.2g/dl；直接胆红素（D-Bil）-6.2mg/dl；铁（Fe）25微克/dl。白色沉淀是由患者血清与ALB、D-Bil和Fe的试剂相互作用形成的。免疫固定电泳显示这些沉淀是IgG4-λ型M蛋白。蛋白质印迹分析表明，IgG4分子由两条55kDa的γ4链和两条24kDa的λ链组成。
