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[惊恐障碍与抗抑郁药]

[Panic disorder and antidepressants].

作者信息

Tsuboi K, Masuko M

机构信息

Department of Psychosomatic Medicine, School of Medicine, Toho University.

出版信息

Nihon Rinsho. 2001 Aug;59(8):1592-8.

Abstract

Anxiety disorders, specifically, panic disorder, are the most common mental health disorders. Unless the clinician has a high index of suspicion, panic disorder or social anxiety disorder may remain undetected. Although quality of life(QOL) issues have long been recognized in severe psychiatric disorders, they have only recently come to be considered for the anxiety disorders. While the older tricyclic antidepressants(TCAs) are efficacious in the treatment of theses anxiety disorders, recent studies with paroxetine and other selective serotonin reuptake inhibitors(SSRIs) have emphasized the role of serotonin in the aetiology of these conditions. Both the TCA and SSRI antidepressants are effective in treating a wide variety of anxiety disorders. SSRIs, due to their greater safety and tolerability, should be the preferred choices in treating anxiety disorders in those instances.

摘要

焦虑症,尤其是惊恐障碍,是最常见的心理健康障碍。除非临床医生有高度的怀疑指数,否则惊恐障碍或社交焦虑障碍可能仍未被发现。虽然生活质量(QOL)问题在严重精神疾病中早已得到认可,但直到最近才开始在焦虑症中被考虑。虽然较老的三环类抗抑郁药(TCAs)在治疗这些焦虑症方面有效,但最近关于帕罗西汀和其他选择性5-羟色胺再摄取抑制剂(SSRIs)的研究强调了5-羟色胺在这些病症病因中的作用。三环类抗抑郁药和选择性5-羟色胺再摄取抑制剂类抗抑郁药在治疗多种焦虑症方面都有效。在那些情况下,由于选择性5-羟色胺再摄取抑制剂类药物具有更高的安全性和耐受性,应该是治疗焦虑症的首选药物。

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