• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

[外科可治疗的癫痫——综述]

[Surgically treatable epilepsy--a review].

作者信息

Janszky J, Rásonyi G, Fogarasi A, Bognár L, Eróss L, Barsi P, Halász P

机构信息

Epilepszia Centrum, Orszagos Pszichiátriai és Neurológiai Intézet, Budapest.

出版信息

Orv Hetil. 2001 Jul 29;142(30):1597-604.

PMID:11519230
Abstract

20-25% of epileptic patients do not become seizure free on adequate drug therapy. In 25-50% of patients with intractable epilepsy, the brain area responsible for seizures is well localizable and does not involve eloquent regions. In these patients, the surgical excision of the epileptic focus may lead to relief from seizures. In Hungary, there may be 5-6000 patients who needs an epilepsy surgery, but till now only 200 patients with chronic epilepsy underwent a surgical procedure. In the surgically remediable epilepsies, the operation is not a "ultima ratio". Concerning these syndromes, if 2-3 adequate antiepileptic drugs do not lead to seizure freedom within 1-3 years after the epilepsy onset, then a presurgical evaluation is necessary. The most common surgically remediable epilepsy is the temporal lobe epilepsy in which 60-90% of drug-resistant patients could be surgically cured. In lesional neocortical epilepsies 50-80% of patients become postoperatively seizure free. In childhood hemispheric epilepsies, the surgery could lead to seizure freedom in 70-80% of patients. The basic tools of the presurgical evaluation are the detailed history, the high resolution-MRI, the video-EEG monitoring, and the neuropsychological assessment. These investigation methods are usually enough to evaluate the necessity of the surgery and the postoperative outcome as well as to plan the localization and the extension of the resection. In some cases, ictal SPECT, PET, or video-EEG monitoring with intracranial electrodes could also be necessary in order to localize the epileptic focus.

摘要

20%至25%的癫痫患者在充分的药物治疗后仍无法实现无癫痫发作。在25%至50%的难治性癫痫患者中,负责癫痫发作的脑区易于定位,且不涉及明确的功能区。对于这些患者,手术切除癫痫病灶可能会缓解癫痫发作。在匈牙利,可能有5000至6000名患者需要进行癫痫手术,但到目前为止,只有200名慢性癫痫患者接受了手术治疗。在可通过手术治愈的癫痫中,手术并非“最终手段”。对于这些综合征,如果在癫痫发作后的1至3年内,使用2至3种充分的抗癫痫药物仍无法实现无癫痫发作,则有必要进行术前评估。最常见的可通过手术治愈的癫痫是颞叶癫痫,其中60%至90%的耐药患者可通过手术治愈。在伴有病灶的新皮质癫痫中,50%至80%的患者术后可实现无癫痫发作。在儿童半球性癫痫中,70%至80%的患者手术后可实现无癫痫发作。术前评估的基本手段包括详细的病史、高分辨率MRI、视频脑电图监测和神经心理学评估。这些检查方法通常足以评估手术的必要性、术后效果以及规划切除的定位和范围。在某些情况下,为了定位癫痫病灶,可能还需要进行发作期单光子发射计算机断层扫描(ictal SPECT)、正电子发射断层扫描(PET)或颅内电极视频脑电图监测。

相似文献

1
[Surgically treatable epilepsy--a review].[外科可治疗的癫痫——综述]
Orv Hetil. 2001 Jul 29;142(30):1597-604.
2
Dynamic changes of ictal high-frequency oscillations in neocortical epilepsy: using multiple band frequency analysis.新皮质癫痫发作期高频振荡的动态变化:采用多频段频率分析
Epilepsia. 2007 Feb;48(2):286-96. doi: 10.1111/j.1528-1167.2007.00923.x.
3
[Surgery for intractable epilepsy--selection and presurgical evaluation].[难治性癫痫的手术治疗——选择与术前评估]
Rinsho Shinkeigaku. 1995 Dec;35(12):1356-60.
4
[Basic and clinical approaches for surgical treatment of intractable epilepsies].[顽固性癫痫外科治疗的基础与临床方法]
Rinsho Shinkeigaku. 1994 Dec;34(12):1237-9.
5
Occipital lobe epilepsy: clinical characteristics, surgical outcome, and role of diagnostic modalities.枕叶癫痫:临床特征、手术结果及诊断方法的作用
Epilepsia. 2005 May;46(5):688-95. doi: 10.1111/j.1528-1167.2005.56604.x.
6
Surgical outcome and prognostic factors of cryptogenic neocortical epilepsy.隐源性新皮质癫痫的手术结果及预后因素
Ann Neurol. 2005 Oct;58(4):525-32. doi: 10.1002/ana.20569.
7
EEG source imaging in pediatric epilepsy surgery: a new perspective in presurgical workup.小儿癫痫手术中的脑电图源成像:术前评估的新视角。
Epilepsia. 2006 Jun;47(6):981-90. doi: 10.1111/j.1528-1167.2006.00550.x.
8
Prognostic factors in neocortical epilepsy surgery: multivariate analysis.新皮质癫痫手术的预后因素:多变量分析
Epilepsia. 2006 Mar;47(3):574-9. doi: 10.1111/j.1528-1167.2006.00470.x.
9
Clinical evaluation and noninvasive electroencephalography. Preoperative evaluation.临床评估与无创脑电图检查。术前评估。
Neuroimaging Clin N Am. 1995 Nov;5(4):547-58.
10
Asymmetric seizure termination in primary and secondary generalized tonic-clonic seizures.原发性和继发性全面性强直-阵挛发作中的不对称发作终止
Epilepsia. 2009 Sep;50(9):2035-9. doi: 10.1111/j.1528-1167.2009.02068.x. Epub 2009 Mar 23.

引用本文的文献

1
Human Glutathione S-Transferase Enzyme Gene Polymorphisms and Their Association With Neurocysticercosis.人类谷胱甘肽 S-转移酶酶基因多态性及其与脑囊虫病的关系。
Mol Neurobiol. 2017 May;54(4):2843-2851. doi: 10.1007/s12035-016-9779-4. Epub 2016 Mar 28.
2
Outcomes of disconnective surgery in intractable pediatric hemispheric and subhemispheric epilepsy.难治性小儿半球及半球下癫痫的离断性手术疗效
Int J Pediatr. 2012;2012:527891. doi: 10.1155/2012/527891. Epub 2012 Feb 9.
3
Cognitive changes following surgery in intractable hemispheric and sub-hemispheric pediatric epilepsy.
难治性小儿半球及半球下癫痫手术后的认知变化
Childs Nerv Syst. 2010 Aug;26(8):1067-73. doi: 10.1007/s00381-010-1102-5. Epub 2010 Feb 24.
4
Expressions of glutathione S-transferase alpha, mu, and pi in brains of medically intractable epileptic patients.谷胱甘肽S-转移酶α、μ和π在药物难治性癫痫患者大脑中的表达。
BMC Neurosci. 2008 Jul 18;9:67. doi: 10.1186/1471-2202-9-67.