Weingold A B
J Reprod Med. 1975 Jun;14(06):244-7.
We have just begun our study of fetal growth retardation. Prenatal influences upon fetal growth are poorly understood and little studied. One may list multiple etiologies, catalogue numerous physiologic processes, and still not know in any given child what went wrong. The questions far exceed our preliminary answers. How does maternal undernutrition significantly effect the fetal "parasite?" Is the syndrome of intrauterine growth retardation a manifestation of a host versus graft phenomenon, with "runting" in the offspring? Are deficits in cell number and size unalterable? Can these deficits be overcome with good postnatal care? How can we better detect the fetus who is undergoing deprivation in utero? What altered biochemical processes exist? Can we reverse such abnormal influences in utero and prevent their consequences to the fetus? Certainly there are numerous additional areas for investigation and thought.
我们刚刚开始对胎儿生长迟缓进行研究。人们对产前因素对胎儿生长的影响了解甚少，相关研究也不多。人们可以列出多种病因，罗列众多生理过程，但在任何一个特定的孩子身上，仍然不知道哪里出了问题。问题远远超出了我们初步的答案。母亲营养不良是如何显著影响胎儿这个“寄生物”的？宫内生长迟缓综合征是否是宿主与移植物现象的一种表现，导致后代“发育不良”？细胞数量和大小的缺陷是否不可改变？这些缺陷能否通过良好的产后护理得到克服？我们如何才能更好地检测出子宫内正在遭受营养剥夺的胎儿？存在哪些改变的生化过程？我们能否在子宫内逆转这种异常影响并防止其对胎儿产生后果？当然，还有许多其他需要研究和思考的领域。
