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在一名同时感染HTLV-1和HIV并患有HAM/TSP及HIV相关痴呆症的患者中枢神经系统中逆转录病毒的定位。

Localization of retrovirus in the central nervous system of a patient co-infected with HTLV-1 and HIV with HAM/TSP and HIV-associated dementia.

作者信息

Levin M C, Rosenblum M K, Fox C H, Jacobson S

机构信息

Department of Neurology, University of Tennessee Health Sciences Center, Memphis 38163, USA.

出版信息

J Neurovirol. 2001 Feb;7(1):61-5. doi: 10.1080/135502801300069719.

DOI:10.1080/135502801300069719
PMID:11519484
Abstract

Persons co-infected with HTLV-1 and HIV are at increased risk for neurologic disease. These patients may develop HAM/TSP and/or HIV-associated dementia. In this study, we localized cells infected with retrovirus in the central nervous system (CNS) of a patient with both HAM/TSP and HIV-associated dementia. HTLV-1 was localized to astrocytes and HIV to macrophage/microglia. There was no co-infection of a single cell phenotype in this patient. These data suggest that mechanisms other than co-infection of the same CNS cell may play a role in the development of neurologic disease in patients dual infected with HTLV-1 and HIV.

摘要

同时感染人类嗜T淋巴细胞病毒1型（HTLV-1）和人类免疫缺陷病毒（HIV）的人患神经疾病的风险会增加。这些患者可能会发展为热带痉挛性截瘫（HAM/TSP）和/或HIV相关痴呆。在本研究中，我们在一名同时患有HAM/TSP和HIV相关痴呆的患者的中枢神经系统（CNS）中定位了感染逆转录病毒的细胞。HTLV-1定位于星形胶质细胞，HIV定位于巨噬细胞/小胶质细胞。该患者不存在单一细胞表型的共同感染。这些数据表明，除了同一中枢神经系统细胞的共同感染外，其他机制可能在HTLV-1和HIV双重感染患者的神经疾病发展中起作用。

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