Kook C S, Reed M F, Digenis G A
J Med Chem. 1975 May;18(5):533-5. doi: 10.1021/jm00239a023.
A procedure is described that permits the preparation of [18F]haloperidol in 140 min at specific activities ranging from 4-5 muCi mg-1. A key step in the synthetic route involves the incorporation of 18F into the molecule through a Schiemann-type reaction, which involves the pyrolysis of the diazonium tetrafluoroborate salt of 4-[4-(p-chlorophenyl)-4-hydroxypiperidino]-4'-aminobutyrophenone.
本文描述了一种在140分钟内制备比活度范围为4 - 5μCi mg⁻¹的[¹⁸F]氟哌啶醇的方法。合成路线中的关键步骤包括通过席曼型反应将¹⁸F引入分子中，该反应涉及4 - [4 - (对氯苯基)-4 - 羟基哌啶基]-4'-氨基丁酰苯四氟硼酸重氮盐的热解。
