Lefebvre Y, Revesz C
J Med Chem. 1975 Jun;18(6):581-3. doi: 10.1021/jm00240a011.
The oxidation of 17alpha-[3-furyl]estradiol derivatives and the estrogenic properties of the resulting isomeric 17,21-and 17,23-dihydroxy-19,24-dinor-17alpha-chola-1,3,5(10)20(22)-tetraenoic acid(20leads to 23) gamma-lactones as well as those of the related 17-hydroxy-19-nor-17alpha-pregna-1,3,5(10)-triene-20,21-dicarboxylic acid anhydrides and gamma-lactones are described. Of these, only lactones 3c,e,h and 5b retained the same degree and profile of estrogenic activity as the starting 17alpha-[3-furyl]estradiols.
描述了17α-[3-呋喃基]雌二醇衍生物的氧化反应，以及所得异构体17,21-和17,23-二羟基-19,24-二降-17α-胆甾-1,3,5(10),20(22)-四烯酸(20→23)γ-内酯以及相关的17-羟基-19-去甲-17α-孕甾-1,3,5(10)-三烯-20,21-二羧酸酐和γ-内酯的雌激素特性。其中，只有内酯3c、e、h和5b保留了与起始17α-[3-呋喃基]雌二醇相同程度和特征的雌激素活性。
