Quantitative structure-activity relationships in the delta6-6-substituted progesterone series. A reappraisal.

A quantitative structure-activity analysis concerning the progestational activity of a series of delta6-6-substituted progesterone is presented which differs from that published recently by other authors. In the current study all compounds in the data set for which parameters are available are included and activity is shown to relate to primarily lipophilic but also steric effects.