异叶酸喹唑啉类似物的合成。
Synthesis of quinazoline analogs of isofolic acid.
作者信息
Hynes J B, Garrett C M
出版信息
J Med Chem. 1975 Jun;18(6):632-4. doi: 10.1021/jm00240a025.
PMID:1151982
Abstract
Four quinazoline analogs of isofolic acid were synthesized including 5-methyl-5,8-deazaisofolic acid (8a), 5,8-deazaisofolic acid (8c), as well as their 4-NH2 counterparts 8b and 8d. None of these showed significant activity against L1210 leukemia in mice at dose levels where amethopterin provided significant prolongation in survival.
摘要
合成了异叶酸的四种喹唑啉类似物，包括5-甲基-5,8-二氮杂异叶酸（8a）、5,8-二氮杂异叶酸（8c）以及它们的4-NH₂对应物8b和8d。在氨甲蝶呤能显著延长小鼠存活时间的剂量水平下，这些化合物对L1210白血病均无显著活性。
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