Guthrie R W, Brossi A, Mennona F A, Mullin J G, Kierstead R W, Grunberg E
J Med Chem. 1975 Jul;18(7):755-60. doi: 10.1021/jm00241a023.
Several acyloxy and alkyl derivatives of ellipticine have been prepared. In addition, a modified synthesis leading to the hitherto unobtainable 8,9-dimethoxy- and 8,9-methylenedioxyellipticines is described. Some of the derivatives described herein exhibit antitumor activity. However, none of the compounds showed activity superior to that of the naturally occurring pyridocarbazoles, ellipticine and 9-methoxyellipticine.
已制备了多种玫瑰树碱的酰氧基和烷基衍生物。此外，还描述了一种改进的合成方法，该方法可得到迄今无法获得的8,9-二甲氧基玫瑰树碱和8,9-亚甲二氧基玫瑰树碱。本文所述的一些衍生物具有抗肿瘤活性。然而，这些化合物均未表现出优于天然存在的吡啶并咔唑类化合物（玫瑰树碱和9-甲氧基玫瑰树碱）的活性。
