伴有罕见变异型费城染色体易位：t(9;10;22)(q34;q22;q11)的慢性髓系白血病
Chronic myeloid leukemia with a rare variant Philadelphia translocation: t(9;10;22)(q34;q22;q11).
作者信息
Emberger W, Behmel A, Tschernigg M, Seewann H L, Petek E, Kroisel P M, Wagner K
机构信息
Institute of Medical Biology and Human Genetics, University of Graz, Harrochgasse 21/8, A-8010 Graz, Austria.
出版信息
Cancer Genet Cytogenet. 2001 Aug;129(1):76-9. doi: 10.1016/s0165-4608(01)00417-4.
We report a 59-year-old, male, chronic myeloid leukemia patient with a rare variant Philadelphia (Ph) translocation t(9;10;22)(q34;q22;q11). Fluorescence in situ hybridization with whole chromosome paints was used to confirm the cytogenetic findings. With a BCR/ABL-specific probe, the known rearrangement on the derivative chromosome 22 was found. The prognostic implications as well as the relevance of the additional breakpoint region 10q22 are discussed.
我们报告了一名59岁男性慢性髓性白血病患者，其存在罕见的变异型费城（Ph）易位t(9;10;22)(q34;q22;q11)。采用全染色体涂染荧光原位杂交技术来确认细胞遗传学结果。使用BCR/ABL特异性探针，在衍生染色体22上发现了已知的重排。讨论了其预后意义以及额外断点区域10q22的相关性。
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