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肾结核当前治疗方案的评估。

An evaluation of the current therapeutic regimen for renal tuberculosis.

作者信息

Wechsler M, Lattimer J K

出版信息

J Urol. 1975 Jun;113(6):760-1. doi: 10.1016/s0022-5347(17)59575-0.

DOI:10.1016/s0022-5347(17)59575-0
PMID:1152148
Abstract

Renal tuberculosis will continue to be a potentially lethal disease and must be considered a diagnostic possibility in all patients with infection in order to discover it in time. Multiple drug regimens have withstood the test of time and it appears that triple drug therapy is more efficacious than 2 drugs since triple drugs permit the skipping of 1 or another of the medications with less danger of relapse. Rifampin is a new drug that is well tolerated and efficacious, although expensive. We recommend continuous use of triple drugs for 2 years at least with the continuance of pyridoxine. We advise an excretory urogram, the collection of 3 urine specimens for culture and the passage of ureteral catheters every 6 months during treatment and every 12 months thereafter for 10 years. We do not consider relapse an indication for an operation but for further therapy, using medications to which the patient's organism is proved susceptible by bacteriologic means. Under modern conditions an operation is rarely necessary.

摘要

肾结核仍将是一种潜在的致命疾病,在所有感染患者中都必须考虑到这种疾病的诊断可能性,以便及时发现。多种药物治疗方案已经经受住了时间的考验,而且似乎三联药物疗法比二联药物疗法更有效,因为三联药物允许跳过一种或另一种药物,复发的危险性较小。利福平是一种新药,耐受性良好且有效,尽管价格昂贵。我们建议至少连续使用三联药物两年,并持续服用吡哆醇。我们建议在治疗期间每6个月进行一次排泄性尿路造影,收集3份尿液标本进行培养,并插入输尿管导管,此后每年进行一次,持续10年。我们不认为复发是手术的指征,而是进一步治疗的指征,即使用通过细菌学方法证明患者机体对其敏感的药物。在现代条件下,很少需要进行手术。

相似文献

1
An evaluation of the current therapeutic regimen for renal tuberculosis.肾结核当前治疗方案的评估。
J Urol. 1975 Jun;113(6):760-1. doi: 10.1016/s0022-5347(17)59575-0.
2
Ethambutol regimen in renal tuberculosis.
J Urol. 1975 Oct;114(4):498-9. doi: 10.1016/s0022-5347(17)67067-8.
3
[Rifampicin in the treatment of lung and kidney tuberculosis].[利福平治疗肺和肾结核]
Ned Tijdschr Geneeskd. 1972 Jan 1;116(1):9-15.
4
Interaction aspects of antimycobacterial drugs in the chemotherapy of tuberculosis. I. Role of individual antituberculous drugs in drug regimens used in the chemotherapy of human tuberculosis.
Chemotherapy. 1974;20(3):165-76. doi: 10.1159/000221806.
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Treatment of tuberculosis today in Nebraska.当今内布拉斯加州的结核病治疗
Nebr Med J. 1973 May;58(5):156-62.
6
Standard therapy for tuberculosis 1985.1985年结核病的标准疗法。
Chest. 1985 Feb;87(2 Suppl):117S-124S. doi: 10.1378/chest.87.2.117s.
7
Newer knowledge of chemotherapy in the treatment of tuberculosis of bones and joints.骨与关节结核治疗中化疗的最新知识。
Clin Orthop Relat Res. 1973 Nov-Dec(97):5-15. doi: 10.1097/00003086-197311000-00002.
8
Genitourinary tuberculosis.泌尿生殖系统结核
Surg Annu. 1974;6:439-57.
9
[Ocular toxicity of ethambutol].[乙胺丁醇的眼部毒性]
Annee Ther Clin Ophtalmol. 1971;22:387-93.
10
[Experimental chemotherapy of tuberculosis].[结核病的实验性化疗]
Z Erkr Atmungsorgane Folia Bronchol. 1969;130(5):417-48.

引用本文的文献

1
Surgical management of renal tuberculosis.肾结核的外科治疗
Indian J Urol. 2008 Jul;24(3):369-75. doi: 10.4103/0970-1591.42620.
2
Imaging of renal tuberculosis in eastern Taiwan: correlation with clinical course and different communities.台湾东部肾结核的影像学表现:与临床病程及不同社区的相关性
Kaohsiung J Med Sci. 2003 Jun;19(6):271-7. doi: 10.1016/S1607-551X(09)70473-5.
3
The changing pattern of renal tuberculosis.肾结核的变化模式
Int Urol Nephrol. 1986;18(2):119-24. doi: 10.1007/BF02082596.