Garbelli R, Frassoni C, Ferrario A, Tassi L, Bramerio M, Spreafico R
Department of Experimental Neurophysiology, Istituto Nazionale Neurologico C. Besta, Via Celoria 11, 20133 Milano, Italy.
Neuroreport. 2001 Aug 28;12(12):2767-71. doi: 10.1097/00001756-200108280-00034.
Cajal-Retzius cells, identified using calretinin antiserum, were studied in layer I (LI) of adult human temporal cortex from epileptic patients with Taylor's focal cortical dysplasia and architectural dysplasia, in comparison with normal cortex. Both types of dysplasia showed LI hypercellularity, but only in architectural dysplasia was the density of Cajal-Retzius cells significantly increased. A subset of Cajal-Retzius cells were reelin immunoreactive, but none were GABA positive. These findings suggest that differences in the persistence of Cajal-Retzius cells, which probably reflect different types of alteration during brain development, can assist in characterizing different forms of cortical dysplasia.
利用钙视网膜蛋白抗血清鉴定出的卡哈尔-雷茨乌斯细胞，在患有泰勒局灶性皮质发育异常和结构发育异常的癫痫患者的成人大脑颞叶皮质第I层（LI）中进行了研究，并与正常皮质进行了比较。两种类型的发育异常均表现为LI细胞增多，但仅在结构发育异常中，卡哈尔-雷茨乌斯细胞的密度显著增加。一部分卡哈尔-雷茨乌斯细胞有Reelin免疫反应性，但均无GABA阳性。这些发现表明，卡哈尔-雷茨乌斯细胞持续存在的差异可能反映了大脑发育过程中不同类型的改变，有助于区分不同形式的皮质发育异常。
