de Tommaso M, Libro G, Guido M, Sciruicchio V, Puca F
Interuniversity Center for the Study of Headache and Neurotransmitter Disorders of the Central Nervous System, Perugia, Roma, Sassari, Bari, Napoli, Firenze, Italy.
Neurosci Lett. 2001 Sep 7;310(1):37-40. doi: 10.1016/s0304-3940(01)02086-9.
Laser stimulation of the supraorbital regions evokes brain potentials (LEPs) related to trigeminal nociception. The aim of this study was to record the R2 component of the blink reflex and the corneal reflex in 20 normal subjects, comparing the scalp activity following these reflexes with the nociceptive potentials evoked by CO2 laser stimulation of supraorbital regions. Cortical and muscular reflexes evoked by stimulation of the first trigeminal branch were recorded simultaneously. The R2 component of the blink reflex and the corneal reflex were followed by two cortical peaks, which resembled morphologically N-P waves of LEPs. The two peaks demonstrated a difference in latency of approximately 40 ms, which is consistent with activation time of nociception. This finding suggests that these reflexes are induced by activation of small pain-related fibers.
激光刺激眶上区域可诱发与三叉神经伤害感受相关的脑电位（LEPs）。本研究的目的是记录20名正常受试者的瞬目反射和角膜反射的R2成分，并将这些反射后的头皮活动与CO2激光刺激眶上区域诱发的伤害性电位进行比较。同时记录刺激三叉神经第一支诱发的皮质和肌肉反射。瞬目反射和角膜反射的R2成分之后有两个皮质峰，其形态类似于LEPs的N-P波。这两个峰的潜伏期差异约为40毫秒，这与伤害感受的激活时间一致。这一发现表明这些反射是由与疼痛相关的小纤维激活所诱发的。
