基因型转座器：用于连锁不平衡分析的自动化基因型操作

Genotype transposer: automated genotype manipulation for linkage disequilibrium analysis.

作者信息

Cox D G, Canzian F

机构信息

Genome Analysis Group, International Agency for Research on Cancer, 69008 Lyon, France.

出版信息

Bioinformatics. 2001 Aug;17(8):738-9. doi: 10.1093/bioinformatics/17.8.738.

DOI:10.1093/bioinformatics/17.8.738

PMID:11524375

Abstract

UNLABELLED

The purpose of this work is to provide the modern molecular geneticist with tools to perform more efficient and more accurate analysis of the genotype data they produce. By using Microsoft Excel macros written in Visual Basic, we can translate genotype data into a form readable by the versatile software 'Arlequin', read the Arlequin output, calculate statistics of linkage disequilibrium, and put the results in a format for viewing with the software 'GOLD'.

AVAILABILITY

The software is available by FTP at: ftp://xcsg.iarc.fr/cox/Genotype_Transposer/.

SUPPLEMENTARY INFORMATION

Detailed instruction and examples are available at: ftp://xcsg.iarc.fr/cox/Genotype&_Transposer/. Arlequin is available at: http://lgb.unige.ch/arlequin/. GOLD is available at: http://www.well.ox.ac.uk/asthma/GOLD/.

摘要

未标注

这项工作的目的是为现代分子遗传学家提供工具，以便他们对自己生成的基因型数据进行更高效、更准确的分析。通过使用用Visual Basic编写的Microsoft Excel宏，我们可以将基因型数据转换成通用软件“Arlequin”可读的形式，读取Arlequin的输出结果，计算连锁不平衡统计量，并将结果整理成可通过软件“GOLD”查看的格式。