Appleton R A, Brown K
Agents Actions Suppl. 1979(4):188-92.
When space-filling models of the peroxy radical precursor of PGG were compared with models of 2(S)-(3-chloro-4-cyclohexylphenyl)propionic acid and other acidic cyclooxygenase inhibitors several common structural features were revealed. This led us to propose a template for synthesising non-steroidal anti-inflammatory drugs (NSAIS's) based on the geometry of the peroxy radical immediately prior to its cyclisation to PGG.
当将PGG过氧自由基前体的空间填充模型与2(S)-(3-氯-4-环己基苯基)丙酸及其他酸性环氧化酶抑制剂的模型进行比较时，发现了几个共同的结构特征。这使我们基于过氧自由基环化形成PGG之前的几何结构，提出了一种合成非甾体抗炎药（NSAIS）的模板。
