Levy J C
Diabetes Research Laboratories, The Oxford Centre for Diabetes, Endocrinology and Metabolism, The Radcliffe Infirmary, UK.
Growth Horm IGF Res. 2001 Jun;11 Suppl A:S17-23. doi: 10.1016/s1096-6374(01)80004-6.
Periodic oscillations appear to be a characteristic of insulin secretion at various different levels. Very rapid pulsations are seen in the isolated beta-cell and islet, while rapid (10- to 15-min) pulsations are seen both in the intact organism and in the isolated pancreas. Ultradian oscillations, particularly evident in situations of sustained exogenous glucose loading, appear to be a characteristic of intact organisms and have been hypothesized to be intrinsic to the normal glucose-insulin feedback system. Many of the features seen in experimental situations and in abnormalities of the system can be predicted by computer modelling of this system, supporting this hypothesis. A further theoretical feature of this hypothesis, borne out by experiment, is the ability to entrain insulin pulsatility by oscillations in an exogenous glucose infusion. Identification of defective ultradian oscillations and entrainment can identify subtle abnormalities of insulin sensitivity and pancreatic function, and restoration of normal function can be demonstrated after pharmaceutical intervention.
周期性振荡似乎是不同水平胰岛素分泌的一个特征。在分离的β细胞和胰岛中可观察到非常快速的脉动，而在完整机体和分离的胰腺中都可观察到快速（10至15分钟）脉动。超日振荡在持续外源性葡萄糖负荷情况下尤为明显，似乎是完整机体的一个特征，并且已被推测为正常葡萄糖-胰岛素反馈系统所固有。该系统的计算机建模可以预测在实验情况和系统异常中所观察到的许多特征，从而支持这一假设。该假设的另一个经实验证实的理论特征是，外源性葡萄糖输注中的振荡能够带动胰岛素的脉动性。识别有缺陷的超日振荡和带动作用可以识别胰岛素敏感性和胰腺功能的细微异常，并且在药物干预后可以证明正常功能得以恢复。
