抗HIV候选药物的进展。第3部分：二芳基嘧啶（DAPY）类似物。
Evolution of anti-HIV drug candidates. Part 3: Diarylpyrimidine (DAPY) analogues.
作者信息
Ludovici D W, De Corte B L, Kukla M J, Ye H, Ho C Y, Lichtenstein M A, Kavash R W, Andries K, de Béthune M P, Azijn H, Pauwels R, Lewi P J, Heeres J, Koymans L M, de Jonge M R, Van Aken K J, Daeyaert F F, Das K, Arnold E, Janssen P A
机构信息
Janssen Research Foundation, Welsh and McKean Roads, Spring House, PA 19477, USA.
出版信息
Bioorg Med Chem Lett. 2001 Sep 3;11(17):2235-9. doi: 10.1016/s0960-894x(01)00412-7.
The synthesis and anti-HIV-1 activity of a series of diarylpyrimidines (DAPYs) are described. Several members of this novel class of non-nucleoside reverse transcriptase inhibitors (NNRTIs) are extremely potent against both wild-type and a panel of clinically significant single- and double-mutant strains of HIV-1.
描述了一系列二芳基嘧啶（DAPYs）的合成及其抗HIV-1活性。这类新型非核苷逆转录酶抑制剂（NNRTIs）中的几个成员对HIV-1的野生型以及一组具有临床意义的单突变和双突变毒株都具有极强的活性。
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