Barcellos L F, Caillier S, Dragone L, Elder M, Vittinghoff E, Bucher P, Lincoln R R, Pericak-Vance M, Haines J L, Weiss A, Hauser S L, Oksenberg J R
Department of Neurology, University of California at San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA.
Nat Genet. 2001 Sep;29(1):23-4. doi: 10.1038/ng722.
A C-->G nucleotide transition in exon 4 of PTPRC (encoding protein-tyrosine phosphatase receptor-type C, also known as CD45) was recently reported to be genetically associated with the development of multiple sclerosis (MS). We performed an extensive evaluation of this polymorphism using large family-based and case-control comparisons. Overall, we observed no evidence of genetic association between the PTPRC polymorphism and MS susceptibility or disease course.
最近有报道称，PTPRC（编码蛋白酪氨酸磷酸酶受体C型，也称为CD45）外显子4中的一个C→G核苷酸转换与多发性硬化症（MS）的发生存在遗传关联。我们使用基于大家庭的研究以及病例对照比较，对这种多态性进行了广泛评估。总体而言，我们没有观察到PTPRC多态性与MS易感性或病程之间存在遗传关联的证据。
