Fukumoto Y, Mori Y, Takagi H, Iwata H, Murase K, Miyauchi T, Umeda Y, Hirose H
First Department of Surgery, Gifu University School of Medicine, Japan.
Prostaglandins Other Lipid Mediat. 2001 Sep;66(2):89-97. doi: 10.1016/s0090-6980(01)00145-9.
This investigation was designed to evaluate the morphological changes of anterior spinal artery (ASA) and its reaction to prostaglandinE1 (PGE1) during aortic cross-clamping. ASA during 30 min cross-clamping was observed with charge-coupled device (CCD) and ASA diameter (ASAD) was measured. Group A: Infrarenal aorta was cross-clamped. Group B: Infrarenal aorta was cross-clamped and aorta above the bifurcation was snared. The aortic segment between clamp and snare was perfused with blood. Group C: PGE1 of 100 ng/kg/min was added to perfusate of Group B. The aortic segmental pressures in group B and C were about 30% of the proximal systolic arterial pressure and were significantly higher than distal pressure of group A. After cross-clamping, ASAD decreased about 80% of before cross-clamping in group A. By segmental perfusion of which pressure was about 30% of proximal systolic arterial pressure, ASAD remained almost 90% in group B. By administration of PGE1, ASAD was significantly increased in group C. The changes of ASAD were significantly different between group A and C, and between group B and C.
本研究旨在评估主动脉交叉阻断期间脊髓前动脉（ASA）的形态变化及其对前列腺素E1（PGE1）的反应。使用电荷耦合器件（CCD）观察30分钟交叉阻断期间的ASA，并测量ASA直径（ASAD）。A组：肾下腹主动脉交叉阻断。B组：肾下腹主动脉交叉阻断，分叉上方的主动脉套扎。夹闭和套扎之间的主动脉段进行血液灌注。C组：在B组的灌注液中加入100 ng/kg/min的PGE1。B组和C组的主动脉段压力约为近端收缩期动脉压的30%，且显著高于A组的远端压力。交叉阻断后，A组的ASAD下降至交叉阻断前的约80%。通过压力约为近端收缩期动脉压30%的节段性灌注，B组的ASAD几乎保持在90%。通过给予PGE1，C组的ASAD显著增加。A组和C组之间以及B组和C组之间ASAD的变化有显著差异。
