D-葡萄糖胺和D-半乳糖胺对小鼠髓样肿瘤（格拉菲氏瘤）和骨髓瘤MOPC-21中尿苷核苷酸浓度的影响。
Effect of D-glucosamine and D-galactosamine on the uridine nucleotide concentration in mouse myeloid tumor (Graffi) and myeloma MOPC-21.
作者信息
Chelibonova-Lorer H
出版信息
Neoplasma. 1975;22(1):23-7.
The effect of D-glucosamine and D-galactosamine on the content of uridine nucleotides in myeloid tumor (Graffi) and myeloma MOPC-21 of mice was investigated in vivo. After treatment with aminosugars a marked decrease in UTP and UDP-glucose quantity was found. The trapping of uridine phosphates by formation of UDP-sugar derivatives was different in the two tumors and depended on the aminosugar employed. D-glucosamine provoked an increase in the UDP-N-acetylglucosamine pool size in myeloid tumor (Graffi) and myeloma MOPC-21. D-galactosamine administration led to formation of UDP-galactosamine and UDP-N-acetylglucosamine in myeloma MOPC-21, while in myeloid tumor (Graffi) an increase in the content of UDP-N-acetylglucosamine was obtained only.
在体内研究了D-葡萄糖胺和D-半乳糖胺对小鼠髓性肿瘤（格拉菲氏瘤）和骨髓瘤MOPC-21中尿苷核苷酸含量的影响。用氨基糖处理后，发现UTP和UDP-葡萄糖的量显著减少。两种肿瘤中通过形成UDP-糖衍生物捕获尿苷磷酸的情况不同，且取决于所使用的氨基糖。D-葡萄糖胺可使髓性肿瘤（格拉菲氏瘤）和骨髓瘤MOPC-21中的UDP-N-乙酰葡萄糖胺池大小增加。给予D-半乳糖胺可导致骨髓瘤MOPC-21中形成UDP-半乳糖胺和UDP-N-乙酰葡萄糖胺，而在髓性肿瘤（格拉菲氏瘤）中仅UDP-N-乙酰葡萄糖胺的含量增加。
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