Use of a protocol to minimize hypersensitivity reactions with asparaginase administration.

Several antineoplastic drugs in clinical use may cause hypersensitivity reactions (HSRs) that range from an occasional individual reaction to a significant HSR. Asparaginase preparations have a high incidence of invoking HSRs. The use of an HSR protocol may minimize symptoms experienced by the patient and ensure rapid implementation of life-saving measures when reactions occur. The article will define HSRs, review occurrences, and include a protocol developed to minimize reactions to asparaginase preparations.