Rammer L, Gerdin B
Nephron. 1975;14(6):433-41. doi: 10.1159/000180477.
Rats were kept for 4 weeks on a dietary regimen with a low or high sodium intake to increase or reduce, respectively, the renin activity of the kidneys and plasma. Fibrinolysis was inhibited by intravenous injection of AMCA and thrombin was infused into the jugular vein, giving rise to heavy intravascular fibrin deposition in the kidneys. Shortly after the thrombin infusion the glomerular filtration rate (GFR) decreased equally in saline-loaded and normal rats. 48 h after the thrombin infusion the GFR was still markedly reduced in saline-deprived and normal rats but had returned to preinfusion values in the saline-loaded rats. The results might indicate that the renin-angiotensin system is involved in the presistence of the renal functional impairment after intravascular coagulation in the rat kidney.
将大鼠分别置于低钠或高钠饮食方案下饲养4周，以分别增加或降低肾脏和血浆中的肾素活性。通过静脉注射氨甲环酸抑制纤维蛋白溶解，并将凝血酶注入颈静脉，导致肾脏中出现大量血管内纤维蛋白沉积。凝血酶注入后不久，生理盐水负荷大鼠和正常大鼠的肾小球滤过率（GFR）均同等程度下降。凝血酶注入48小时后，缺生理盐水大鼠和正常大鼠的GFR仍显著降低，但生理盐水负荷大鼠的GFR已恢复至注入前水平。这些结果可能表明，肾素-血管紧张素系统参与了大鼠肾脏血管内凝血后肾功能损害的持续存在。
