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[颈部肌张力障碍发病机制的外周机制]

[Peripheral mechanisms of the pathogenesis of cervical dystonia].

作者信息

Petrova L A, Orlova O R, Golubev V L, Dubanova E A

出版信息

Zh Nevrol Psikhiatr Im S S Korsakova. 1999;99(1):42-5.

PMID:11530459
Abstract

Peripheral mechanisms of pathogenesis and formation of the symptoms of cervical dystonia (spastic torticollis--ST) were investigated. By means of orthopedic diagnosis and analysis of motor stereotype, traumas, algesic syndrome in 40 patients with ST, it was found a "short leg" on the side, opposite to the rotation of the head, frequent postural loads on the head and on the neck before ST rise, and algesic and other sensory symptoms in the same region. The data of neuromyography and of evoked skin sympathetic potentials show a presence of pathologic changes in sympathetic autonomic fibers as well as in axons of accessory nerve at both sides, mainly at the left. Such alterations were mainly peripheral and were found more frequently in a group of left-sided ST. The correlations observed between a side of the rotation of a head and a side of peripheral factor, permitted to suppose that peripheral factors (the factor of a "short leg" mainly) determined frequently a side of the rotation of the head. So, ST therapy must influence the peripheral mechanisms, but not only the central ones.

摘要

对颈肌张力障碍(痉挛性斜颈——ST)症状的发病机制及形成的外周机制进行了研究。通过对40例ST患者进行骨科诊断、运动刻板分析、创伤及痛觉综合征分析,发现头旋转对侧存在“短腿”现象,ST发作前头部和颈部频繁承受姿势负荷,且同一区域存在痛觉及其他感觉症状。神经肌电图和诱发皮肤交感神经电位数据显示,双侧尤其是左侧的交感自主神经纤维以及副神经轴突存在病理变化。此类改变主要在外周,且在左侧ST组中更常见。观察到的头部旋转侧与外周因素侧之间的相关性,使得推测外周因素(主要是“短腿”因素)常常决定了头部旋转的方向。因此,ST的治疗必须影响外周机制,而不仅仅是中枢机制。

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