Shakirov D F
Gig Sanit. 2001 Jul-Aug(4):53-6.
This paper gives data on the levels of cytochromes of B5, P450, P420, P450 + P420, on the rates of amidopyrinum N-demethylation and aniline n-hydroxylation in the tissues of the lung, liver, kidney of experimental rats upon acute and chronic (4-month) inhalation exposure to pseudocumol and durol at a concentration of 10 mg/m3. Acute and chronic inhalation exposures to the xenobiotics in this concentration result in activation of microsomal monooxygenases in the tissues of experimental rats in relation to the type of exposure.
本文给出了实验大鼠在急性和慢性(4个月)吸入浓度为10mg/m³的均三甲苯和连三苯后,其肺、肝、肾组织中细胞色素B5、P450、P420、P450 + P420的水平,以及氨基比林N-脱甲基化和苯胺N-羟基化的速率数据。在此浓度下对这些异生物质进行急性和慢性吸入暴露,会导致实验大鼠组织中的微粒体单加氧酶根据暴露类型被激活。