Studies on absorption and elimination of drugs. Part III. Kinetic of distribution and elimination of 2-p-methoxy- and 2-p-bromophenylindandione-1,3 in rabbits.

Distribution and elimination constants, half-times, plasma clearance and volume of distribution for 2-p-methoxy (AID) and 2-p-bromophenylindandione-1,3 (Br-PID) were estimated, basing on a two-compartment open pharmacokinetic models. Differences were found when similar processes of distribution and elimination of PID and its p- chloro, bromo and methoxy derivatives were compared.