Villalobos-Arámbula A.R., Rivas F., Sandoval L., Perea F.J., Casas-Castañeda M., Cantu J.M., Ibarra B.
División de Genética, Centro de Investigación Biomédica de Occidente, CMNO, IMSS, Doctorado en Genética Humana, CUCS, Guadalajara, México.
Am J Hum Biol. 2000 Mar;12(2):201-206. doi: 10.1002/(SICI)1520-6300(200003/04)12:2<201::AID-AJHB5>3.0.CO;2-H.
The haplotypes of 97 beta(A) independent chromosomes from a Mexican Huichol Native American group were analyzed. The analysis also included 87 beta(A) chromosomes from a Mexican Mestizo population previously studied. Among Huichols, eight different 5' beta haplotypes (5Hps) were observed, with types 1(+ - - - -), 13(+ + + - +) and 2(- + + - +) at frequencies of 0.794, 0.093, and 0.041, respectively. In Mestizos, 17 5Hps were found, types 1, 3(- + - + +), 2, 5(- + - - +) and 9(- - - - -) being the most common at frequencies of 0.391, 0.172, 0.092, 0.069, and 0.046, respectively. 3' haplotype (3Hps) frequency distributions were 0.443(+ +), 0.083(+ -), and 0.474(- +) in Huichols and 0.563(+ +), 0.149(+ -), and 0.287(- +) in Mestizos. Pairwise comparison for both haplotype distributions between the two populations showed significant differences. Pairwise distributions of 3Hps for Huichols were compared with nine worldwide populations, three African, two Asian, two Melanesian, one Caucasian, and one United States Native American. The distributions of the Huichol were different (P < 0.05) from all populations except the Native American. Nei's genetic distances showed the Huichols to be closer to the Native Americans, followed by Melanesians from Vanuatu and Asians; Africans were the farthest. The 5Hp distributions in Mexicans were also compared with 23 worldwide populations (including African, Native American, Asian, Caucasian, and Pacific Islanders). Huichol distributions were different (P < 0.05) from all other populations except Koreans. The Mestizo distribution was also different from the others, except three Caucasian groups. Nei's genetic distance between the same populations disclosed that the Huichols are in relatively close proximity to five out of six Asian populations considered. The same analysis with grouped worldwide populations showed Native Americans as population closest to the Huichols, followed by Pacific Islanders and Asians. Present observations are consistent with an important Asian contribution to the Huichol genome in this chromosomal region. Am. J. Hum. Biol. 12:201-206, 2000. Copyright 2000 Wiley-Liss, Inc.
对来自墨西哥惠乔尔印第安人群体的97条β(A)独立染色体的单倍型进行了分析。该分析还包括先前研究过的来自墨西哥梅斯蒂索人群体的87条β(A)染色体。在惠乔尔人中，观察到8种不同的5'β单倍型（5Hps），其中1型（+-+- -）、13型（++++ +）和2型（-++- +）的频率分别为0.794、0.093和0.041。在梅斯蒂索人中，发现了17种5Hps，1型、3型（-+-++）、2型、5型（-+- - +）和9型（---- -）最为常见，频率分别为0.391、0.172、0.092、0.069和0.046。惠乔尔人的3'单倍型（3Hps）频率分布为0.443（++）、0.083（+-）和0.474（-+），梅斯蒂索人的频率分布为0.563（++）、0.149（+-）和0.287（-+）。对这两个人群体的两种单倍型分布进行成对比较，结果显示存在显著差异。将惠乔尔人的3Hps成对分布与9个全球群体进行了比较，其中包括3个非洲群体、2个亚洲群体、2个美拉尼西亚群体、1个高加索群体和1个美国印第安人群体。除了美国印第安人群体之外，惠乔尔人的分布与所有其他群体都不同（P<0.05）。内氏遗传距离显示，惠乔尔人与美国印第安人最为接近，其次是来自瓦努阿图的美拉尼西亚人和亚洲人；非洲人距离最远。还将墨西哥人的5Hp分布与23个全球群体（包括非洲人、美国印第安人、亚洲人、高加索人和太平洋岛民）进行了比较。除了韩国人之外，惠乔尔人的分布与所有其他群体都不同（P<0.05）。梅斯蒂索人的分布也与其他群体不同，除了3个高加索群体。对相同群体之间的内氏遗传距离分析表明，惠乔尔人与所考虑的6个亚洲群体中的5个相对接近。对全球群体进行分组后的相同分析表明，美国印第安人是与惠乔尔人最接近的群体，其次是太平洋岛民和亚洲人。目前的观察结果与亚洲人在该染色体区域对惠乔尔人基因组有重要贡献这一观点一致。《美国人类生物学杂志》12:201 - 206，2000年。版权所有2000年威利 - 利斯公司。
