Sitnik N A, Tokmacheva E V, Savvateeva-Popova E V
I. P. Pavlov Institute of Physiology, Russian Acad. Sci., 199034, St. Petersburg, Nab. Makarova, 6, Russia.
Ross Fiziol Zh Im I M Sechenova. 2001 Jun;87(6):795-800.
Drosophila proved to be a very convenient model for genetic dissection of learning and memory in a number of experimental paradigms. A battery of mutations affecting either different subdomains of the central complex (CC) or of the mushroom bodies (MBs) enable the elucidation of the role of these central brain structures in different forms of learning and memory formation. We tested the CC mutants cexKS181 and ccbKS127 and MBs mutants mud1, mbm1 and cxbN71 for their ability for learning and memory formation in the conditioned courtship suppression paradigm. All the mutants were able to learn but demonstrated different memory defects. While the ccbKS127 mutant was normal in respect to memory formation, the cexKS181 mutant was defective in 30-min. and 3-hour memory; mud1 demonstrated a reduced 3-hour memory.
果蝇被证明是在许多实验范式中对学习和记忆进行遗传剖析的非常方便的模型。一系列影响中央复合体（CC）或蘑菇体（MBs）不同亚域的突变，使得能够阐明这些中枢脑结构在不同形式的学习和记忆形成中的作用。我们在条件性求偶抑制范式中测试了CC突变体cexKS181和ccbKS127以及MBs突变体mud1、mbm1和cxbN71的学习和记忆形成能力。所有突变体都能够学习，但表现出不同的记忆缺陷。虽然ccbKS127突变体在记忆形成方面正常，但cexKS181突变体在30分钟和3小时记忆方面存在缺陷；mud1表现出3小时记忆减退。
