Guthrie S D, Murphy Q R
Proc Soc Exp Biol Med. 1975 Jun;149(2):554-8. doi: 10.3181/00379727-149-38849.
The hepatic K+-mobilizing effects of phenylephrine and isoproterenol were studied in dogs equipped with chronic indwelling portal vein catheters. Animals anesthetized with sodium pentobarbital, received intraportal injections of these sympathomimetic amines, alone or in combination, before and after alpha, or beta, or combined adrenergic blockade. Hepatic K+ movements were assessed by measuring systemic arterial and hepatic venous K+ levels. It was concluded that adrenergic blockade exerted no significant influence on the ability of these agents to provoke the initial release and subsequent uptake of K+ by the liver.
在装有慢性留置门静脉导管的犬中研究了去氧肾上腺素和异丙肾上腺素的肝脏钾动员作用。用戊巴比妥钠麻醉的动物，在α或β或联合肾上腺素能阻断前后，单独或联合经门静脉注射这些拟交感胺。通过测量体循环动脉和肝静脉的钾水平来评估肝脏钾的移动。得出的结论是，肾上腺素能阻断对这些药物引发肝脏最初释放钾以及随后摄取钾的能力没有显著影响。
