El-Banna H M, Ismail A A
Pharmazie. 1975 Apr;30(4):226-8.
Regulating the cooling rate of paracetamol melt resulted in the formation of different microcrystalline structures of the solidified melt. Dissolution rate studies were carried out on powdered samples prepared from fused paracetamol that was crystallized under different conditions. Rapid cooling associated with stirring the melt during crystallisation produced a fast rate of dissolution in the order of two times greater than the untreated drug. Increased dissolution rate data were masked to some extent when working with tablets prepared from the corresponsing solidified and powdered melts. The present study represent a new method of physical modification of drugs as a means of increasing rate of drug dissolution and absorption.
调节扑热息痛熔体的冷却速率会导致凝固熔体形成不同的微晶结构。对由在不同条件下结晶的熔融扑热息痛制备的粉末样品进行了溶出速率研究。在结晶过程中搅拌熔体并快速冷却，产生的溶出速率比未处理的药物快约两倍。当使用由相应的凝固和粉末状熔体制备的片剂时，增加的溶出速率数据在一定程度上被掩盖了。本研究代表了一种药物物理改性的新方法，作为提高药物溶出和吸收速率的一种手段。
