高剂量组胺处理的大鼠胃、十二指肠和结肠有丝分裂活性降低。
Decreased mitotic activity in the stomach, duodenum and colon of rats treated with high doses of histamine.
作者信息
Pishva N, Mann M, Abtahi F S, Djahanguiri B
出版信息
Pharmacology. 1975;13(1):1-4. doi: 10.1159/000136878.
PMID:1153499
Abstract
Histamine in doses of 25, 50, 100 and 200 mg/kg significantly inhibited mitotic activity of the stomach, duodenum and colon of rats. With the above doses this effect is not dose dependent. However, only the highest dose produced acute gastric mucosal ulceration. It is suggested that decreased mitotic activity is not causally related to ulcer provocation.
摘要
25、50、100和200毫克/千克剂量的组胺显著抑制大鼠胃、十二指肠和结肠的有丝分裂活性。使用上述剂量时，这种作用与剂量无关。然而，只有最高剂量会导致急性胃黏膜溃疡。提示有丝分裂活性降低与溃疡诱发没有因果关系。
Zotero 插件