Franklin J D, Reynolds V H, Page D L
Plast Reconstr Surg. 1975 Sep;56(3):277-85.
The survival of melanoma patients is directly related to the involvement of regional nodes and to the microscopic level of invasion of the tumor. During the past 10 years, with the increased use of aggressive surgical therapy (wide local excision or re-excision of the primary tumor and prophylactic dissection of predictably involved regional nodes) the 5-year survival rate has more than doubled. The 5-year survival has doubled in those patients with regional lymph node involvement who were infused for 5 days with L-phenylalanine mustard. Perfusion of the lower extremities with L-phenylalanine mustard has been abandoned at Vanderbilt. The potential aggressiveness of a specific melanoma can be predicted, and thus an appropriate treatment may be planned.
黑色素瘤患者的生存率与区域淋巴结受累情况以及肿瘤的微观浸润程度直接相关。在过去10年中，随着积极手术治疗（广泛局部切除或再次切除原发肿瘤以及对可预测受累的区域淋巴结进行预防性清扫）的使用增加，5年生存率增加了一倍多。那些区域淋巴结受累且接受5天苯丙氨酸氮芥灌注的患者，其5年生存率也增加了一倍。范德比尔特大学已放弃用苯丙氨酸氮芥对下肢进行灌注。特定黑色素瘤的潜在侵袭性是可以预测的，因此可以制定适当的治疗方案。
