Edwards A D, Shekunov B Y, Kordikowski A, Forbes R T, York P
Drug Delivery Group, School of Pharmacy, University of Bradford, BD7 1DP, United Kingdom.
J Pharm Sci. 2001 Aug;90(8):1115-24. doi: 10.1002/jps.1065.
Pure anhydrous polymorphs of carbamazepine were prepared by solution-enhanced dispersion with supercritical fluids (SEDS). Crystallization of the polymorphs was studied. Mechanisms are proposed that consider the thermodynamics of carbamazepine, supersaturation in the SEDS process, and the binary phase equilibria of organic solvents and the carbon dioxide antisolvent. alpha-Carbamazepine was crystallized at high supersaturations and low temperatures, beta-carbamazepine crystallized from a methanol-carbon dioxide phase split, and gamma-carbamazepine crystallized via nucleation at high temperatures and low supersaturation.
通过溶液增强分散超临界流体（SEDS）法制备了卡马西平的纯无水多晶型物。对多晶型物的结晶过程进行了研究。提出的机制考虑了卡马西平的热力学、SEDS过程中的过饱和度以及有机溶剂与二氧化碳抗溶剂的二元相平衡。α-卡马西平在高过饱和度和低温下结晶，β-卡马西平从甲醇-二氧化碳相分离中结晶，γ-卡马西平在高温和低过饱和度下通过成核结晶。
