Gregory L J, O'Neill M J, Nunn J A, Gray J A, Williams S C
Department of Neurology, Guy's, King's and St. Thomas' School of Medicine, King's College, London, UK.
J Magn Reson Imaging. 2001 Sep;14(3):207-14. doi: 10.1002/jmri.1175.
Early neuropathology following a prolonged duration of four-vessel occlusion (4 VO) ischemia in the rat was charted using magnetic resonance imaging (MRI). Animals received either 30 minutes of 4 VO (N = 6) or sham operation (N = 6) prior to in vivo assessment. Proton density and T(2) and combined T(2)/diffusion-weighted (T(2)/DW) MRI were performed at 6, 24, and 72 hours postocclusion. T(2)/DW imaging was the most effective sequence for delineating between injured and intact tissues, indicating neuropathology in the dorsolateral striatum at 24 hours and in the CA1/CA2 subfields of the hippocampus at 72 hours following ischemia. Apparent diffusion coefficient values were significantly reduced in the striatum (P = 0.03) and hippocampus (P = 0.005) at 24 and 72 hours, respectively. This is the first report, to our knowledge, of T(2)/DW imaging detecting lesions following 4 VO in accord with the known temporal evolution of ischemic brain damage.
利用磁共振成像（MRI）绘制了大鼠四血管闭塞（4VO）长时间缺血后的早期神经病理学变化。在进行体内评估之前，动物接受了30分钟的4VO（N = 6）或假手术（N = 6）。在闭塞后6小时、24小时和72小时进行质子密度、T(2)以及联合T(2)/扩散加权（T(2)/DW）MRI检查。T(2)/DW成像对于区分损伤组织和完整组织最为有效，显示在缺血后24小时背外侧纹状体以及72小时海马体的CA1/CA2亚区出现神经病理学变化。在24小时和72小时时，纹状体（P = 0.03）和海马体（P = 0.005）的表观扩散系数值分别显著降低。据我们所知，这是首篇关于T(2)/DW成像检测4VO后病变且与缺血性脑损伤已知时间演变相符的报告。
