立体特异性氘代脱氧鬼臼毒素的合成及脱氧鬼臼毒素的¹H-核磁共振归属
Synthesis of stereospecifically deuterated desoxypodophyllotoxins and 1H-nmr assignment of desoxypodophyllotoxin.
作者信息
Pullockaran A J, Kingston D G, Lewis N G
机构信息
Department of Chemistry, Virginia Polytechnic Institute and State University, Blacksburg 24061-0212.
出版信息
J Nat Prod. 1989 Nov-Dec;52(6):1290-5. doi: 10.1021/np50066a015.
PMID:11536618
Abstract
[4 beta- 2H1]Desoxypodophyllotoxin [3], [4 alpha- 2H1]desoxypodophyllotoxin [4], and [4, 4- 2 H2]desoxypodophyllotoxin [9] were prepared from podophyllotoxin [1] via its chloride [5]. A complete assignment of the 1H-nmr spectrum of desoxypodophyllotoxin [2] was made on the basis of the spectra of the deuterated compounds [3] and [4].
摘要
[4β-2H₁]脱氧鬼臼毒素[3]、[4α-2H₁]脱氧鬼臼毒素[4]和[4,4-2H₂]脱氧鬼臼毒素[9]由鬼臼毒素[1]经其氯化物[5]制备而成。基于氘代化合物[3]和[4]的光谱，对脱氧鬼臼毒素[2]的¹H-核磁共振光谱进行了完整归属。
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