Bohler C, Hill A R, Orgel L E
The Salk Institute for Biological Studies, San Diego, CA 92186-5800, USA.
Orig Life Evol Biosph. 1996 Feb;26(1):1-5. doi: 10.1007/BF01808155.
Treatment of relatively concentrated aqueous solutions of O-phospho-serine (50 mM), aspartic acid (100 mM) or glutamic acid (100 mM) with carbonyldiimidazole leads to the formation of an activated intermediate that oligomerizes efficiently. When the concentration of amino acid is reduced tenfold, few long oligomers can be detected. Positively-charged cetyltrimethyl ammonium bromide micelles concentrate the negatively-charged activated intermediates of the amino acids at their surfaces and catalyze efficient oligomerization even from dilute solutions.
用羰基二咪唑处理相对浓缩的O-磷酸丝氨酸（50 mM）、天冬氨酸（100 mM）或谷氨酸（100 mM）水溶液会导致形成一种能有效寡聚的活化中间体。当氨基酸浓度降低十倍时，几乎检测不到长的寡聚物。带正电荷的十六烷基三甲基溴化铵胶束将带负电荷的氨基酸活化中间体聚集在其表面，并即使从稀溶液中也能催化高效寡聚。
