Lehtonen E, Snow M H
Department of Pathology, University of Helsinki, Finland.
Adv Space Res. 1989;9(11):201-8. doi: 10.1016/0273-1177(89)90074-4.
Gravity has been identified as a morphogenetic signal in Amphibian and bird embryonic development so it is plausible that it might be such in mammals as well. Since early mammalian development shows some apparently significant differences to these other groups, a brief summary of mouse embryogenesis will be given identifying events in which polarity is an important feature and consequently, in which gravity may be a causative factor. These include compaction and polarization during cleavage, establishment of the radial axis, the embryonic-abembryonic axis, the dorso-ventral axis, and the anterior-posterior axis, implantation, and the later rotation of the embryo. The experimental data on these morphogenetic steps will be discussed and an assessment of the possible involvement of gravity will be made.
重力已被确认为两栖动物和鸟类胚胎发育中的一种形态发生信号，因此它在哺乳动物中也可能如此，这是有道理的。由于早期哺乳动物发育与其他这些类群存在一些明显的显著差异，因此将简要概述小鼠胚胎发生过程，确定极性是一个重要特征的事件，因此也是重力可能是一个致病因素的事件。这些事件包括卵裂期间的致密化和极化、径向轴、胚胎 - 反胚胎轴、背 - 腹轴和前 - 后轴的建立、着床以及胚胎后期的旋转。将讨论这些形态发生步骤的实验数据，并对重力可能的参与情况进行评估。
